Kinetic and NMR Spectroscopic Studies of the Fusion Reactions of Chloropurines with 1,2,3,5-Tetra-<I>O</I>-acetyl-D-ribofuranoses
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概要
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A kinetic study of the fusion reaction and the reaction in dimethyl sulfoxide of 2,6-dichloropurine with 1,2,3,5-tetra-<I>O</I>-acetyl-β-D-ribofuranose was undertaken, and both of them were proved to be of the second order. The activation energy and the activation entropy of the reaction in dimethyl sulfoxide were obtained: <I>E</I><SUB>a</SUB>=38.0 kcal/ mol and <I>ΔS</I><SUP>\neweq</SUP>=+15.3 cal · mol. The reaction was thus concluded to be bimolecular involving a considerable unimolecular character. Subsequently, the fusion reactions of 2,6-dichloro- and 2,6,8-trichloropurine with 1,2,3,5-tetra-<I>O</I>-acetyl-α- and -β -D-ribofuranose were examined by NMR spectroscopy with respect to the relative content ratios of all the materials and products in each reaction mixture; the results were found to be in good agreement with those obtained by the above kinetic study. On the basis of these results, the mechanism of the fusion reaction was discussed.
- 公益社団法人 日本化学会の論文
著者
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Ishido Yoshiharu
Department Of Chemistry Tokyo Institute Of Technology
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Sato Tetsuo
Departmelet Of Organic Chemistry Tokyo Institute Of Technology Ookayama
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Hosono Akira
Department of Applied Biological Chemistry, The University of Tokyo
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Sato Tetsuo
Department of Chemistry, Faculty of Science, Tokyo Institute of Technology
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Fujii Kiyohisa
Department of Chemistry, Faculty of Science, Tokyo Institute of Technology
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Tada Toshizo
Department of Chemistry, Faculty of Science, Tokyo Institute of Technology
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Tanaka Hisayuki
Department of Chemistry, Faculty of Science, Tokyo Institute of Technology
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Ohgo Yohko
Department of Chemistry, Faculty of Science, Tokyo Institute of Technology
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Hosono Akira
Department of Chemistry, Faculty of Science, Tokyo Institute of Technology
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