On the Mechanism of the Acid Catalysis and New Activating Agents in the Fusion Reaction of an Acylated Sugar with a Purine Derivative
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概要
- 論文の詳細を見る
An examination of the site where the acidic catalysts might strongly interact in the fusion reaction of a purine derivative with a fully-acylated sugar led to the conclusion that a purine derivative was activated by the interaction with the catalysts, and, moreover, resulted in the discovery of a new type of activating agent other than the acidic catalysts which had previously been known in the fusion method. In the presence of an excess amount of activating agents, <I>e.g.</I>, <I>p</I>-nitrophenol, the condensation reaction of theophylline with 1,2,3,4,6-penta-<I>O</I>-acetyl-β-D-glucopyranose proceeded, even in the absence of <I>p</I>-toluenesulfonic acid, to give the corresponding nucleoside. Some of the activating agents were found to form molecular compounds with theophylline, and a few of the latter to afford the corresponding nucleoside similarly. A possible mechanism for the activation process of theophylline by the above agents was discussed.
- 公益社団法人 日本化学会の論文
著者
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Ishido Yoshiharu
Department Of Chemistry Tokyo Institute Of Technology
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Tanaka Hisayuki
Department of Chemistry, Faculty of Science, Tokyo Institute of Technology
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Yoshino Teruo
Department of Chemistry, Faculty of Science, Tokyo Institute of Technology
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Sekiya Masao
Department of Chemistry, Faculty of Science, Tokyo Institute of Technology
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