Mutants of the Nematode Caenorhabditis elegans That Are Defective Specifically in Their Attraction to Cycloheximide(MISCELLANEOUS)
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概要
- 論文の詳細を見る
The nematode Caenorhabditis elegans exhibits chemotaxis toward a wide variety of chemicals including water-soluble molecules and volatile organic compounds. We have previously discovered that C. elegans wild-type strain N2 is strongly attracted by cycloheximide which has long been known as a bitter tastant for humans and other mammals. We describe here the isolation and initial characterization of the first mutants which were defective specifically in their attraction to cycloheximide. In our screenings, we selected two mutants that were defective in chemotaxis to cycloheximide but normal in their attraction to NH_4Cl and histidine. These mutants also avoided quinine hydrochloride, CuSO_4, and high concentrations of NaCl similar to the wild-type strain N2. Furthermore, no observable defect was detected in their attraction to volatile odorants such as isoamyl alcohol and diacetyl. Dye-filling experiments suggested that they have no morphological defect in the sensory endings of the amphid neurons.
- 社団法人日本生物工学会の論文
- 2003-08-25
著者
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Ohtake Hisao
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Kato Junichi
Department Of Cardiology Asahikawa Medical College
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KURODA Akio
Department of Molecular Biotechnology, Hiroshima University
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Ohtake H
Department Of Biotechnology Osaka University
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Ohtake Hisao
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Ohtake H
Institute Of Applied Microbiology University Of Tokyo
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Ohtake Hisao
Institute Of Applied Microbiology The University Of Tokyo
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Ohtake Hisao
Department Of Fermentation Technology Hiroshima University
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Kato J
Department Of Molecular Biotechnology Hiroshima University
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IKEDA TSUKASA
Department of Fermentation Technology, Hiroshima University
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TAKIGUCHI NOBORU
Department of Fermentation Technology, Hiroshima University
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TAJIMA TAKAHISA
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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Kuroda A
Department Of Molecular Biotechnology Hiroshima University
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Kuroda Akio
Department Of Molecular Biotechnology Hiroshima University
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Kato Junichi
Department Of Agricultural Biological Chemistry College Of Bioresource Sciences Nihon University
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Kato J
Department Of Chemical Engineering Faculty Of Engineering Shizuoka University
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Ikeda Tsukasa
Department Of Applied Chemistry Utsunomiya University
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Ikeda T
Dep. Of Material And Environmental Chemistry Graduate School Of Engineering Utsunomiya Univ.
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Takiguchi Noboru
Department Of Molecular Biotechnology Hiroshima University
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Takiguchi Noboru
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Kato Junichi
Department Of Agricultural Chemistry University Of Tokyo
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Ikeda T
Osaka Medical Coll. Osaka
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Kuroda Akio
Department Of Chemistry Faculty Of Science Nagoya University
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Tajima Takahisa
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
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