Benzoylcarbinol誘導体のシロネズミの腎高血圧性の血管病変に及ぼす影響

概要

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It was reported recently that some types of the derivatives of benzoylcarbinol have a function to restore the altered vascular permeability and also anti-inflammatory activities, probably acting as a mediator through the adrenal cortex. In the view of this point the present experiment was undertaken to know whether the drug inhibits in any degree the occurrence of the damages to the medium-sized and/or small arteries in many organs of rats suffering from renal hypertension. The later was produced by the conventional method of the renal mass reduction. Renal hypertensive rats, given daily 50 mg and 25 mg of Benzoylcarbinol trimethylacetate respectively per kg for either 12, 22 or 40 days, revealed a moderate to significant reduction of both extent and degree of the arterial lesions in the abdominal organs examined histologically, when compared with those of control rats. Such a reduction was not found in the hypertensive rats with daily administration of 100mg/kg/day throughout the experiments. The drug, when administered to the renal hypertensive rats, was observed to have no function to decrease elevated blood pressure, measured by the plethysmography method, even in rats of a high dose group.
社団法人日本循環器学会の論文
1968-06-20