D-ArabonolactoneおよびD-Arabonic acidの急性および亜急性毒性に関する研究

概要

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Recently it was reported that D-arabonolactone (AL), when mixed with meat sausage at the ratio of 1 : 200,reduces the pH and prevents effectively from its decay. It is known that in an aqueous solution AL hydrolyzes to D-arabonic acid, until they reach the equilibrium. For tho purpose of knowing the acute and subacutetoxicity of AL and AA, this experiment was carried out using approximately 200 young inbred mice of both sexes. Seven days LD_<50> of AL was 13.3-10.6 g/kg and that of AA was 10.1-7.8 g/kg. In the experiment of acute intoxication, high doses groups (1/2.5 LD_<50> per day for 7 days) of both drugs showed slightly retarded growth curves compared with that of control. There was no abnormal growth curve in other groups of both drugs. In the subacute intoxication series, retarded growth curve was observed only in AA high doses group (1/4 LD_<50> per day for 3 months). During the experiment of the subacute intoxication of both drugs, 2 out of 60 mice were died spontaneously. The one belonged to AL high doses group and the other to AL middle doses group. Histological examination of all groups of mice, either AL-or AA-treated and acute or subacute, revealed no significant changes in any organs, which seemed to be produced by the ingested drugs.
公益社団法人日本薬学会の論文
1966-04-30