AN AUTOPSY CASE OF HEPATOCELLULAR CARCINOMA PRESENTING MAIN CLINICAL SIGNS OF COMPLETE SPINAL TRANSECTION

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We have recently seen a case of hepatocellular carcinoma, in which the initial symptoms were paraplegy and sensory disturbance of the lower extremities without obvious hepatic signs. The radiological interpretation, at that time, revealed massive tumor formations in the thoracic vertebral column and the paravertebral space. During admission, signs of the complete spinal transection were noted, later followed by hepatic failure, and respiratory insufficiency due to metastatic lung cancer. At autopsy hepatocellular carcinoma with Miyake B' cirrhosis of the liver was noted, associated with metastases to the thoracic vertebrae and paravertebral connective tissue. The spinal cord in the affected vertebra revealed transverse compression necrosis due to such bone metastases. The present case is very rare and literatures concerning bone metastasis of hepatocellular carcinoma with its clinical manifestation are reviewed.
財団法人日本消化器病学会の論文