α-Tocopherol Status and Expression of α-Tocopherol Transfer Protein in Type 2 Diabetic Goto-Kakizaki Rats
スポンサーリンク
概要
- 論文の詳細を見る
Vitamin E, a critical fat-soluble vitamin antioxidant, is expressed on cell membranes and prevents propagation of lipid peroxidation. α-Tocopherol transfer protein (α-TTP) is a cytosolic protein located in the hepatocytes that acts as the principal regulator of the circulating α-tocopherol levels. Type 2 diabetes is a metabolic disorder characterized by hyperglycemia, caused by insulin resistance. Lipid peroxidation promotes the clinical progression and development of complications in type 2 diabetes. Results of animal and human experiments on the vitamin E status in diabetes are conflicting. The present study was conducted with the objective of investigating the vitamin E status and α-TTP expression in Goto-Kakizaki (GK) rats, a model of type 2 diabetes. In diabetic GK rats, increases of the α-tocopherol levels in the plasma and liver were observed as compared with the levels in the controls. No alternation in the CuZn-superoxide dismutase (SOD) or Mn-SOD gene expression was found in the liver of GK rats as compared with that in the controls. The GK rats showed an increase of the hepatic expression of the α-TTP gene as compared with the level in the controls. It can be suggested that the increased hepatic α-TTP gene expression levels may influence plasma α-tocopherol levels in the diabetic animals. Hence, investigation of the regulatory factors of α-TTP expression may provide important clues to highlighting the antioxidant mechanisms of vitamin E.
著者
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TAMAI Hiroshi
Department of Pediatrics, Osaka Medical College
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Tamai Hiroshi
Department Of Fusion Plasma Research Japan Atomic Energy Research Institute
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Koh Maki
Department Of Pediatrics Osaka Medical College Hospital
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Takaya Ryuzo
Department Of Pediatrics Osaka Medical College
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Takitani Kimitaka
Department Of Pediatrics Osaka Medical College
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Yoden Atsushi
Department Of Pediatrics Osaka Medical College
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Miyazaki Hiroshi
Department Applied Physics Tohoku University
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Miyazaki Hiroshi
Department of Pediatrics, Osaka Medical College
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