α-Tocopherol Status and Expression of α-Tocopherol Transfer Protein in Type 2 Diabetic Goto-Kakizaki Rats

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概要

• 論文の詳細を見る

• Vitamin E, a critical fat-soluble vitamin antioxidant, is expressed on cell membranes and prevents propagation of lipid peroxidation. α-Tocopherol transfer protein (α-TTP) is a cytosolic protein located in the hepatocytes that acts as the principal regulator of the circulating α-tocopherol levels. Type 2 diabetes is a metabolic disorder characterized by hyperglycemia, caused by insulin resistance. Lipid peroxidation promotes the clinical progression and development of complications in type 2 diabetes. Results of animal and human experiments on the vitamin E status in diabetes are conflicting. The present study was conducted with the objective of investigating the vitamin E status and α-TTP expression in Goto-Kakizaki (GK) rats, a model of type 2 diabetes. In diabetic GK rats, increases of the α-tocopherol levels in the plasma and liver were observed as compared with the levels in the controls. No alternation in the CuZn-superoxide dismutase (SOD) or Mn-SOD gene expression was found in the liver of GK rats as compared with that in the controls. The GK rats showed an increase of the hepatic expression of the α-TTP gene as compared with the level in the controls. It can be suggested that the increased hepatic α-TTP gene expression levels may influence plasma α-tocopherol levels in the diabetic animals. Hence, investigation of the regulatory factors of α-TTP expression may provide important clues to highlighting the antioxidant mechanisms of vitamin E.

著者

• TAMAI Hiroshi

  Department of Pediatrics, Osaka Medical College

• Tamai Hiroshi

  Department Of Fusion Plasma Research Japan Atomic Energy Research Institute

• Koh Maki

  Department Of Pediatrics Osaka Medical College Hospital

• Takaya Ryuzo

  Department Of Pediatrics Osaka Medical College

• Takitani Kimitaka

  Department Of Pediatrics Osaka Medical College

• Yoden Atsushi

  Department Of Pediatrics Osaka Medical College

• Miyazaki Hiroshi

  Department Applied Physics Tohoku University

• Miyazaki Hiroshi

  Department of Pediatrics, Osaka Medical College

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