β-Carotene 15,15'-Dioxigenase Activity in Streptozotocin-Induced Diabetic Rats
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概要
- 論文の詳細を見る
We measured retinol levels and β-carotene 15, 15-dioxygenase activity in rats with streptozotocin-induced diabetes mellitus to assess the relationship between the dis-ease and the conversion of β-carotene to retinol. The plasma retinol level was significantly lower in diabetic rats than in control rats, but the hepatic retinol level was significantly higher than the control. The hepatic dioxygenase activity, but not that of the intestinal mu-cosa, was significantly lower in diabetic rats than in control rats. The hepatic dioxygenase activity showed a significant negative correlation with the hepatic retinol levels. The results suggest the disturbed secretion of retinol from the liver and suppression of hepatic dioxy-genase activity by the retinol increased in the liver in diabetic rats.
- 財団法人 学会誌刊行センターの論文
- 2000-10-01
著者
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Tamai Hiroshi
Department Of Fusion Plasma Research Japan Atomic Energy Research Institute
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MORINOBU Takao
Department of Pediatrics, Osaka Medical College
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Morinobu Takao
Department Of Pediatrics Osaka Medical College
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