Altered Expression of Both β-Carotene 15,15'Monooxygenase and Lecithin : Retinol Acyltransferase in Obese Zucker Rats
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概要
- 論文の詳細を見る
Retinol and its active derivative retinoic acid have an important role in development, reproduction, immunity, and cell proliferation/differentiation. Obesity and dyslipidemia are risk factors for cardiovascular disease that may affect hepatic homeostasis. It is unclear whether the expression of retinol-related proteins is affected and influences the retinol status in obesity and dyslipidemia. The aim of this study was to evaluate the retinol status and expression of retinol-metabolizing enzymes and binding protein in obese and dyslipidemic fa/fa (Zucker) rats. We examined the expression of genes for β-carotene 15,15 monooxygenase (BCM), lecithin:retinol acyltransferase (LRAT), cellular retinol binding protein-I (CRBP-I), and cytochrome P450 26A1 (CYP26A1) in fa/fa rats and lean control rats. We also measured the retinol level in plasma and liver samples from both groups. Plasma retinol levels in fa/fa rats were increased compared with lean rats, while hepatic retinol levels were similar in both groups. In obese and dyslipidemic fa/fa rats, intestinal BCM gene expression was increased, whereas hepatic LRAT gene expression was deceased. There was no difference in hepatic CRBP-I and CYP26A1 gene expression between fa/fa rats and lean rats. Altered expression of BCM and LRAT genes may affect plasma retinol status in obesity and dyslipidemia.
- 2011-02-01
著者
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HIGUCHI KAZUHIDE
Department of Gastroenterology and Hematology, Osaka Medical College
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Tamai Hiroshi
Department Of Fusion Plasma Research Japan Atomic Energy Research Institute
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Takaya Ryuzo
Department Of Pediatrics Osaka Medical College
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Tamai Hiroshi
Department Of Pediatrics Osaka Medical College
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Miyazaki Hiroshi
Department Of Cardiology Kyoto First Red Cross Hospital
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Higuchi Kazuhide
Department Of Gastroenterology And Hepatology Osaka Medical College
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Takitani Kimitaka
Department Of Pediatrics Osaka Medical College
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FUKUNISHI Shinya
Department of Legal Medicine, Osaka Medical College
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YODEN Atsushi
Department of Pediatrics, Osaka Medical College
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Miyazaki Hiroshi
Department Of Pediatrics Osaka Medical College
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Yoden Atsushi
Department Of Pediatrics Osaka Medical College
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Miyazaki Hiroshi
Department Of Applied Physics Tohoku University
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Fukunishi Shinya
Department Of Legal Medicine Osaka Medical College
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Miyazaki Hiroshi
Department Applied Physics Tohoku University
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Higuchi Kazuhide
Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan
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