Pharmacokinetics of Low-Dose All-trans Retinoic Acid in Japanese Children with Cancer
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概要
- 論文の詳細を見る
All-trans retinoic acid (ATRA) is used as differentiation therapy for acute promyelocytic leukemia (APL). The two major adverse effects of ATRA therapy are hyperleukocytosis and retinoic acid syndrome. In order to prevent these adverse effects, low-dose ATRA therapy (25 mg/m^2/d) has been tried in adults. Accordingly we assessed the pharmacokinetics of low-dose ATRA in children with cancer. Four children (one with APL and three with other advanced cancer) were administered ATRA and its pharmacokinetics were evaluated. In three patients, the pharmacokinetic parameters of ATRA were similar to those previously determined for APL patients in remission, but the values were lower in one patient. Low-dose ATRA was effective for APL, but not for the solid tumors. This therapy did not cause any severe toxicity. Further studies are needed to determine the optimum ATRA regimen and to evaluate low-dose ATRA combined with chemotherapy in children with APL.
- 日本ビタミン学会の論文
著者
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TAMAI Hiroshi
Department of Pediatrics, Osaka Medical College
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KAWAKAMI Chihiro
Department of Pediatrics, Osaka Medical College Hospital
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INOUE Akiko
Department of Pediatrics, Osaka Medical College Hospital
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KOH Maki
Department of Pediatrics, Osaka Medical College Hospital
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TAKITANI Kimitaka
Department of Pediatrics, Osaka Medical College Hospital
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Miyake M
Department Of Pediatrics Osaka Medical College
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Miyake Munenori
Department Of Pediatrics Osaka Medical College
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Tamai Hiroshi
Department Of Fusion Plasma Research Japan Atomic Energy Research Institute
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Koh Maki
Department Of Pediatrics Osaka Medical College Hospital
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Inoue Akiko
Department Of Dermatology Osaka Kaisei Hospital
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Inoue Akiko
Department Of Pediatrics Osaka Medical College Hospital
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Tamai H
Department Of Pediatrics Osaka Medical College Hospital
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Mino Makoto
Department Of Pediatrics Osaka Medical College
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KAWAMURA Naohisa
Department of Pediatrics, Osaka Medical College
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KUNO Tomoko
Department of Pediatrics, Osaka Medical College
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Kuno T
Department Of Pediatrics Osaka Medical College
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Takitani Kimitaka
Department Of Pediatrics Osaka Medical College
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Inoue Akiko
Department Of Chemical And Biological Sciences Japan Women's University
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Kawakami Chihiro
Osaka Medical Coll. Takatsuki Jpn
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Kawakami Chihiro
Department Of Pediatrics Osaka Medical College
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Kawamura Naohisa
Department Of Pediatrics Osaka Medical College
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Kuno Tomoko
Department Of Pediatrics Osaka Medical College
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