Resolution of Cranial MRI and SPECT Abnormalities in a Patient with Wilson's Disease Following Oral Zinc Monotherapy
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概要
- 論文の詳細を見る
A 38-year-old woman with Wilson's disease developed neurological deterioration after 25 years of low-dose penicillamine administration. She showed an akinetic-rigid syndrome and cerebellar motor ataxia. Brain MRI showed increased signal intensity at the bilateral pons, midbrain, putamen, and thalamus. 123I-IMP-SPECT revealed a diffuse reduction of cerebral blood flow at the bilateral cerebral hemisphere including the basal ganglia. After the patient's regimen was changed to zinc therapy, her neurological condition gradually improved, and she showed almost complete recovery within two years. Serial MRI and SPECT studies showed a marked improvement in the lesions.
著者
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Hanafusa Toshiaki
The First Department of Internal Medicine, Osaka Medical College
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Kimura Fumiharu
The First Department Of Internal Medicine
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Tamai Hiroshi
Department Of Fusion Plasma Research Japan Atomic Energy Research Institute
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Kimura Fumiharu
The First Department of Internal Medicine, Osaka Medical College, Japan
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Ishida Shimon
The First Department of Internal Medicine, Osaka Medical College, Japan
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Doi Yoshimitsu
The First Department of Internal Medicine, Osaka Medical College, Japan
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Yamane Kazushi
The First Department of Internal Medicine, Osaka Medical College, Japan
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Sugino Masakazu
The First Department of Internal Medicine, Osaka Medical College, Japan
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Fukui Hideo
The Second Department of Internal Medicine, Osaka Medical College, Japan
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Tamai Hiroshi
Department of Pediatrics, Osaka Medical College, Japan
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