Glycated Albumin to Glycated Hemoglobin Ratio is a Sensitive Indicator of Blood Glucose Variability in Patients with Fulminant Type 1 Diabetes
スポンサーリンク
概要
- 論文の詳細を見る
Background Since serum albumin is glycosylated more rapidly than hemoglobin, it is possible that the glycated albumin (GA) to HbA1c ratio (GA: HbA1c ratio) is potentially a more sensitive indicator of blood glucose excursion than HbA1c. The aim of the present study was to assess the clinical usefulness of GA: HbA1c ratio as a marker of daily glucose excursions in patients with type 1 diabetes according to the subtypes; acute onset type 1A, fulminant and slowly progressive type 1 diabetes. Methods Fifty-six outpatients with type 1 diabetes [16 fulminant, 20 acute-onset type 1A and 20 slowly progressive (SPIDDM)] were recruited consecutively. Each patient performed self-monitoring of blood glucose at seven points a day. The associations among the daily profile of glucose and GA, HbA1c, GA: HbA1c ratio were examined across and within the subtypes of type 1 diabetes. Results GA and GA: HbA1c ratio were each independently correlated with mean amplitude of glucose excursion (MAGE) in patients with type 1 diabetes (F=27.53, p<0.001 and F=13.02, p<0.001, respectively). GA: HbA1c ratio was significantly higher in fulminant type 1 diabetic patients than in SPIDDM patients (3.5 ± 0.2 vs. 3.2 ± 0.5, p=0.015) and it was independently associated with MAGE within fulminant type 1 diabetes (F=21.2, p<0.001). Conclusion In conclusion, the present study demonstrated that GA: HbA1c ratio could be a better marker for glycemic variability than HbA1c in type 1 diabetes, especially in fulminant type 1 diabetes.
著者
-
Hanafusa Toshiaki
The First Department of Internal Medicine, Osaka Medical College
-
Murase-Mishiba Yuko
The First Department of Internal Medicine, Osaka Medical College, Japan
-
Matsumoto Hiroaki
The First Department of Internal Medicine, Osaka Medical College, Japan
-
Yamamoto Naomune
The First Department of Internal Medicine, Osaka Medical College, Japan
-
Sugitatsu-Nakatsukasa Saya
The First Department of Internal Medicine, Osaka Medical College, Japan
-
Shibasaki Saeko
The First Department of Internal Medicine, Osaka Medical College, Japan
-
Sano Hiroyuki
The First Department of Internal Medicine, Osaka Medical College, Japan
-
Terasaki Jungo
The First Department of Internal Medicine, Osaka Medical College, Japan
-
Imagawa Akihisa
The First Department of Internal Medicine, Osaka Medical College, Japan
関連論文
- PE-517 P-selectin and Tissue Inhibitor of Metalloproteinase-2 But Not Soluble CD40 Ligand May Predict Rupture in Patients with Abdominal Aortic Aneurysm(Peripheral circulation-3 (H) PE87,Poster Session (English),The 70th Anniversary Annual Scientific Meet
- PE-341 The Longitudinal Calcification Length in Multi-slice Computed Tomography May be Available to Detect the Coronary Artery Stenosis(CT/DSA-5 (I) PE57,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation S
- PE-317 Angiotensin Receptor 1 Blocker Inhibits Atherosclerotic Changes of Aortic Valve by Preserving Endothelial Cells and Inhibiting Transformation into Osteoblast Phenotype(Vascular heart disease/Pericarditis/Cardiac tumor-2 (M) PE53,Poster Session (Eng
- PE-169 What Factors Determine Whether a Patient Experience a Sudden Rupture or Live for Many Years?(Atherosclerosis, clinical-8 (H) PE29,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-047 Angiotensin II Type1 Receptor Blocker, Olmesartan Inceases Plaque Stability with Altering Macrophage Activation in Rabbit Plaque Model(Atherosclerosis, basic-3 (H) PE8,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the J
- Placental Growth Factor is a Useful Marker as a Target of Therapeutic Intervention (Atherosclerosis, Clinical 10 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Angiotensin Receptor 1 Blocker Reduces Atherosclerotic Changes of Aortic Valve in Hypercholesteremic Rabbit Model(Valvular Heart Disease/Pericarditis/Cardiac Tumor 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Resolution of Cranial MRI and SPECT Abnormalities in a Patient with Wilson's Disease Following Oral Zinc Monotherapy
- Glycated Albumin to Glycated Hemoglobin Ratio is a Sensitive Indicator of Blood Glucose Variability in Patients with Fulminant Type 1 Diabetes