<Originals>Effect of a single intravenous dose of bisphosphonate (pamidronate) on tibial cortical bone after lengthening
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概要
- 論文の詳細を見る
The tibiae of 15 young rabbits were osteotomized and lengthened gradually to produce a gap of 1 cm over a period of 10 days, and then one dose of 0.6 mg/kg of bisphosphonate (pamidronate disodium) was injected intravenously into 5 of them. The bone mineral density (BMD) in the proximal and distal portions of the tibia and lengthened callus was evaluated using dual energy X-ray absorptiometry every 5 days for 30 days after lengthening had been completed. In the control rabbits the BMD in the distal and proximal diaphyseal portions of the tibiae continuously decreased to about 50% 15 days after completion of lengthening. In the treated rabbits, however, the BMD increased until day 10 in the proximal portion and until day 5 in the distal portion, with the difference being significant in the proximal portion. It was demonstrated that a single pamidronate dose could inhibit bone resorption in an area of high bone turnover. The stimulatory effect of a single dose on the mineralization of the lengthened callus, however, was not significant. Experiments using repetitive doses of pamidronate for longer periods should be mandatory.
- 近畿大学の論文
著者
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HAMANISHI Chiaki
Department of Orthopedic Surgery, School of Medicine, Kinki University
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TANAKA Seisuke
Department of Orthopaedic Surgery, Kinki University School of Medicine
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MIYAZAKI Hiroshi
Department of Internal Medicine III, Kurume University School of Medicine
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Hamanishi Chiaki
Department Of Orthopaedic Surgery Kinki University School Of Medicine
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Hamanishi Chiaki
Department Of Orthopedic Surgery Kinki University School Of Medicine
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Tanaka Seisuke
Department Of Orthopaedic Surgery Faculty Of Medicine Kyoto University
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YOSHII Takeo
Department of Orthopedic Surgery, Kinki University School of Medicine
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Miyazaki H
Department Of Hematology Kumamoto University School Of Medicine
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Miyazaki Hiroshi
Department Applied Physics Tohoku University
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Yoshii Takeo
Department Of Orthopedic Surgery Kinki University School Of Medicine
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