Inositol derivatives. 10. Isopropylidenation of 1,2-O-cyclohexylidene-myo-inositol derivatives and preparation of unaccessible blocked inositols.

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概要

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• Isopropylidenation of 1,2-<I>O</I>-cyclohexylidene-<I>myo</I>-inositol and its 3-<I>O</I>-tosyl- and 3-<I>O</I>-benzoyl derivatives with 2,2-dimethoxypropane in <I>N</I>,<I>N</I>-dimethylformamide in the presence of acid catalyst gave the corresponding 4,5- and 5,6-<I>O</I>-isopropylidene derivatives. Selective benzoylation of 1,2-<I>O</I>-cyclohexylidene-4,5-<I>O</I>-isopropylidene-<I>myo</I>-inositol with benzoyl chloride in pyridine gave mainly the 3-<I>O</I>-benzoate, whereas with benzoic anhydride the 6-<I>O</I>-benzoate. Several unaccessible blocked inositols were prepared by displacement reaction of the protected sulfonyl derivatives with sodium benzoate.

• 公益社団法人 日本化学会の論文

著者

• Ogawa Seiichiro

  Department Of Applied Cemistry Faculty Of Science And Technology Keio University

• Suami Tetsuo

  Department of Applied Chemistry Faculty of Engineering Keio University

• Oki Shuichi

  Department of Applied Chemistry, Faculty of Engineering, Keio University

• Kunitomo Hideo

  Department of Applied Chemistry, Faculty of Engineering, Keio University

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