Hydrazinolysis of Sugar Sulfonates

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概要

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• Hydrazinolysis of methyl 4,6-di-<I>O</I>-acetyl-2,3-di-<I>O</I>-tosyl-α-D-glucopyranoside (I) or methyl 2,6-di-<I>O</I>-benzoyl-3,4-di-<I>O</I>-mesyl-α-D-glucopyranoside (VI), followed by catalytic hydrogenation and acetylation, afforded methyl 2,4-diacetamido-3,6-di-<I>O</I>-acetyl-2,4-dideoxy-α-D-idopyranoside (II). Also methyl 2,3-di-<I>O</I>-acetyl-4,6-di-<I>O</I>-mesyl-α-D-glucopyranoside (VII) was treated analogously as described above to give methyl 4,6-diacetamido-2,3-di-<I>O</I>-acetyl-4,6-dideoxy-α-D-galactopyranoside (IX). The structures were studied by means of proton magnetic resonance spectra. And a reaction mechanism was also discussed.

• 公益社団法人 日本化学会の論文

著者

• Shoji Tadao

  Department Of Pharmacology Eisai Tsukuba Research Laboratories

• Suami Tetsuo

  Department of Applied Chemistry Faculty of Engineering Keio University

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