Synthesis of potential antineoplastic anthracenedione derivatives. II. 1,2-Dihydroxy derivatives.

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概要

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• In continuation of the preceding paper in this series, four derivatives of 1,2-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-9,10-anthracenedione: a positional isomer of mitoxantrone have been prepared to establish a relationship between the position of the hydroxyl groups on the A ring and antineoplastic activity against experimental leukemia L1210 in mice. Two compounds were found to be fairly active.

• 公益社団法人 日本化学会の論文

著者

• NAKAMURA Katsumi

  Department of Agricultural Chemistry, The University of Tokyo:(Present office)Department of Biological and Chemical Engineering, Gunma University

• HARA Tamio

  Department of Mathematics Faculty of Engineering Science University of Tokyo

• Suami Tetsuo

  Department of Applied Chemistry Faculty of Engineering Keio University

• Asai Tomoyuki

  Department of Applied Chemistry, Faculty of Science and Technology, Keio University

• Minorikawa Naoki

  Department of Applied Chemistry, Faculty of Science and Technology, Keio University

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