Nucleoside Analogs. II. A Synthesis of 9-Adenyl-deoxyinositols

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概要

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• Four 9-adenyl-deoxyinositols were prepared by a reaction between 4-amino-6-chloro-5-nitropyrimidine (<B>1</B>) and inosamines (<B>2a</B>, <B>2b</B>, <B>2c</B>, and <B>2d</B>), followed by a reduction and a cyclization. In the present article, 1-(6′-amino-9′-purinyl)-1-deoxy-<I>scyllo</I>-inositol (<B>5a</B>), 1-(6′-amino-9′-purinyl)-1-deoxy-<I>muco</I>-inositol (<B>5b</B>), 2-(6′-amino-9′-purinyl)-2-deoxy-<I>epi</I>-inositol (<B>5c</B>), and 2-(6′-amino-9′-purinyl)-2-deoxy-<I>myo</I>-inositol (<B>5d</B>) were described. These compunds exhibited an inhibitory effect against <I>piricularia</I> <I>oryzae</I>.

• 公益社団法人 日本化学会の論文

著者

• Suami Tetsuo

  Department of Applied Chemistry Faculty of Engineering Keio University

• Tsukamoto Yoko

  Department of Applied Chemistry, Faculty of Engineering Keio University

• Fukai Yasushi

  Department of Applied Chemistry, Faculty of Engineering Keio University

• Sakota Yukio

  Department of Applied Chemistry, Faculty of Engineering, Keio University

• Karimoto Makoto

  Department of Applied Chemistry, Faculty of Engineering Keio University

• Takoi Nobuo

  Department of Applied Chemistry, Faculty of Engineering Keio University

• Sakota Yukio

  Department of Applied Chemistry, Faculty of Engineering Keio University

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