ヒトおよび魚類血液における凝集能の比較〔英文〕

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Aggregation behaviors of human platelets and carp Cyprinus carpio, rainbow trout Salmo gairdneri, and red seabream Pagrus major thrombocytes were studied by an electronic aggregometer and microscopic observation.Measurement was done by using electronic aggregometer. The irreversible aggregation responses were recognized in all rainbow trout and red seabream blood similar to human blood with the addition of sodium arachidonate (AA). However, the response of thrombocytes in carp blood was not induced by the addition of AA, but the reversible aggregation response was recognized in four out of twelve samples. The aggregation was not induced by the addition of sodium eicosapentaenoate (EPA) or docosahexaenoate (DHA) in fish blood like human blood. It is assumed that the differences in prostaglandin (PG) syntheses among them cause the different behaviors in the blood aggregation.Moreover, in the microscopic observation, human platelets and all fish thrombocytes aggregated in the presence of ionophore A23187, thrombin, and collagen, but did not aggregate in the presence of EPA, DHA, PGF2α, PGD2, or ADP. On the other hand, in the presence of AA, PGE2 and platelet activating factor (PAF), the aggregating responses varied among species tested.
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