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Antibody forming cells against TNP-SRBC were induced to a simillar extent when the peripheral blood mononuclear cells from normal, patients with chronic active hepatitis or asymptomatic HBV carriers were stimulated in vitro with pokeweed mitogen (PWM). Although these antibody responses were significantly augmented by adding the estrogen simultaneously with PWM to the mononuclear cells cultures prepared from normal or patients with chronic active hepatitis, no such augmentation of antibody response by estrogen were demonstrable in asymptomatic carriers. The DNA synthesis in PWM-stimulated mononuclear cells was also increased by estrogen in normal or patients with chronic active hepatitis, but this was not the case in asymptomatic carriers.These observations suggest that a factor (or factors) may correlate with the induction of asymptomatic carrier state such as a unresponsiveness to the estrogen at least partially.
財団法人日本消化器病学会の論文