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The liver cell injury induced by antibody-dependent cell-mediated cytotoxic reaction in vitro was significantly augmented by the culture supernatant prepared from the estrogen-treated macrophages. When this estrogen-treated macrophage culture fluid was fractionated by gel filtration using a Sephadex G-75 column, the active material causing the enhancement of ADCC was found in a relatively low molecular size as interleukin-1. Since this active fraction was also shown to enhance the thymocyte responsiveness to the mitogenic stimulation, it was assumed that interleukin-1 might be produced from estrogen-treated macrophages and this might cause an augmentation of ADCC. On the contrary, this augmentative antibody-dependent cell-mediated hepatocytotoxicity by estrogen-treated macrophage culture supernatant fraction was abolished when macrophages were treated by estrogen in the presence of testosterone. In this case, no incresed responsiveness of thymocytes to the mitogen was also demonstrated.
財団法人日本消化器病学会の論文