薬物アレルギ-性胆汁うっ滞患者の血清中に認められた催胆汁うっ滞因子について

概要

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When the blood serum from patient with drug-induced allergic intrahepatic cholestasis was fractionated by a Sephadex G-75 gel filtration and the certain fraction was injected into mesenteric vein of rats, a marked reduction of bile flow was seen. Similar results were obtained when peripheral lymphocytes from the patient were stimulated with a specific drug in vitro in the presence of soluble liver specific protein fraction and the certain fraction which was fractionated with a Sephadex G-75 gel filtration followed by a DEAE-cellulose column chromatography was injected into mesenteric vein of rats. Histologically, a dilated bile canaliculus with the diminution of microvilli and increased vesicles around the dilated canaliculi were observed by an electron microscopy after injection of culture supernatant fraction into rats.<BR>These results strongly suggest that not only the sensitized lymphocytes produce the cholestatic factor (factors) which causes the intrahepatic cholestasis, but also this factor involves significantly in the pathogenesis of intrahepatic cholestasis which frequently observes in the patients with drug-induced allergic hepatitis.
社団法人日本肝臓学会の論文