慢性活動性肝炎における肝特異抗原に対する細胞性免疫を介在するmacrophage-mediated cytotoxicityの関与について

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Possible involvement of the cell-mediated immunity responses to liver specific antigen in the pathogenesis of liver injury was investigated. The subjects were composed of 7 patients with acute hepatitis, 12 cases with chronic active hepatitis, 4 cases with chronic inactive hepatitis and 3 cases with liver cirrhosis.<BR>When the peripheral blood lymphocytes from these patients were cultured with the liver specific antigen and lymphocyte transformation was estimated by the uptake of 3H-thymidine to the acid-insoluble materials, blastogenesis was found in 2 cases with acute hepatitis and in 6 cases with chronic active hepatitis.<BR>The macrophage activating factor (MAF), a kind of lymphokine, was also detected in the culture medium of activated lymphocytes from 6 patients who showed positive blastogenesis. This was estimated by the uptake of 3H-glucosamine into the macrophages.<BR>The activated macrophages by MAF were shown to be cytotoxic to the separated liver cells causing the marked inhibition of albumin synthesis. These macrophage-mediated cytotoxicity was detected in all 8 cases who showed the positive lymphocyte transformation.<BR>These observations suggest that the macrophage-mediated cytotoxicity may play an role in the pathogenesis of chronic active hepatitis.
社団法人日本肝臓学会の論文