魚類組織におけるNAD(P)分解酵素の存在と分布

概要

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It was confirmed by thin-layer chromatography that NAD and NADP were finally degraded into nicotinamide and adenosine by the enzymes present in the crude extract of skipjack liver. The first step of the degradation was catalyzed by three hydrolases, NAD(P) nucleosidase, nucleotide pyrophosphatase and alkaline phosphatase. NMN, one of the reaction products, was further degraded into nicotinamide by the action of alkaline phosphat-ase and purine nucleosidase. The liver showed the highest activities of the three hydrolases followed by the kidney. The activity of NAD(P) nucleosidase was highest in cardiac muscle. All four of the enzyme activities were extremely low in boty dark and ordinary muscle. This was also the case with the yellowtail. In skipjack liver, these enzymes were, for the most part, distributed in the cytoplasm excepting mitochondria.
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