2P1-D16 機能性マイクロツールを用いたオンチップ細胞計測システム(ナノ・マイクロ流体システム)

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This paper reports on local injection of functional microtool in a microchip to develop on-chip cell measurement system using functional microtool. To achieve this, local alignment of the microtool inside the microgroove fabricated on the glass substrate using surface tension and gravity force was developed. This local alignment is performed by dropping the solution impregnated with microtools to the edge of the tool holder. Then the solution fills the microgroove and microtools are aligned into the microgroove autonomously. Our developed microtool is made of hydrophilic photo-crosslinkable resin, of which the primary constituent is polyethylene glycol (PEG). Aligned microtools do not adhere to the microgroove because PEG does not make a nonspecific bonding and is non-charged polymer. Aligned microtool could be manipulated by optical tweezers. We succeeded in local injection of the microtool into the workspace and on-chip cell experiment such as cell transport, immobilization and local measurement using functional microtools.
2008-06-06