1A1-C25 機能性ゲルマイクロツールを用いた脂質ナノチューブの水中ハンドリング

概要

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We developed a novel technique to handle a lipid nanotube by laser tweezers in water solutions. Laser tweezers are suitable for manipulation of a single microscopic object. Single cell manipulation is important for biological research works, and advanced techniques such as 3D manipulation are much useful for measurement and environmental control around the cell. Here we aim to develop 3D manipulation technique that can manipulate several objects with different shapes. For this purpose, first we developed functional gel-microtools. We can manipulate nano-micro objects easily with the gel-microtools. We succeeded in controlling the position and orientation of a lipid nanotude by using 3D Synchronized Laser Micromanipulation and novel functional microtools. Second, we newly developed an observation system to improve blurring of image by synchronization of shutter timing of CCD camera and laser scanning. With this system, we can obtain clear image of the targets for 3D manipulation.