2A1-O05 オンチップ細胞操作システムに関する研究 : その2 : 高精度ポリマー製マイクロ磁気ツールの製作と応用(ナノ・マイクロ流体システム)

概要

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In this paper we describe novel magnetically driven polymeric microtool for non-intrusive and no contamination experiments on a chip. The composite is formed by suspending magnetite particles (Fe_3O_4) in polydimethylsiloxane (PDMS). In order to obtain precise and complicated pattern of micromagnetic tools, a photolithography techniques has been applied by making good use of thick KMPR-1050 photoresist as sacrificed mould. The surface of the produced micromagnetic tools are coated in order to suppress stiction in the biochip. The novelties of these tools are 1. fabrication of any shape, 2.soflness (harmless to cells), 3. no contact actuation (no stiction), 4. mass production with low cost and disposable. Here we have demonstrated that the mass-produced versatile micromagnetic tools such as stirrer and valve. The potential impact of this technology includes sample selection and separation, cell immobilization, mixing and reaction techniques into portable microfluidic labs-on-a-chip, and long term culture systems and cell loading system.
一般社団法人日本機械学会の論文
2007-05-11