2P2-J16 孔密度の傾斜を有する多層構造の人工血管足場開発(ナノ・マイクロバイオシステム)

概要

論文の詳細を見る
In the field of regenerative medicine, tissue engineering has gotten a lot of attention. Especially in the department of vascular regeneration, biodegradable vascular constructions play an important role for the regeneration of blood vessel. In this work, we propose a multi-layered vascular scaffold with porosity -gradient and stiffness-gradient in radial direction. Higher porosity at inner layer will help HUVECs to be attached while lower porosity at outer layer supports the mechanical strength of the scaffold. Multi - layered biodegradable tube with gradient porosity will be a good tool to investigate the speed of degradation after implantation. It also proposes that it will be able to avoid the possibility of intimal thickening or lack of endothelial cells.
一般社団法人日本機械学会の論文
2008-06-06