2P2-J15 磁性果糖ビーズの自己組織化を利用した多孔質生分解性足場の造形(ナノ・マイクロバイオシステム)

概要

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Technologies to develop scaffolds with controlled pore layout and porosity have great significance in tissue engineering. In this paper, we describe a novel approach to fabricate 2D and 3D porous biodegradable scaffolds made of PLCL by using magnetic sugar particles as porogens. First, ferrite micro/nano particles were encapsulated in sugar microspheres to make them magnetized. After sieving magnetic sugar particles, those diameter-controlled particles were attracted by a magnetic force to form an assembled template for polymer casting. A magnetic field with polka-dot pattern was also utilized to align particles on desired positions. After polymer casting and removal of the sugar template, spherical pores were generated inside scaffold. For future application in vascular tissue engineering, we extended the scaffold fabrication to straight tubular scaffolds by winding 2D porous sheets on sacrificial molds. The biocompatibility of the developed scaffold was confirmed by viable cells after 4-day culture.
一般社団法人日本機械学会の論文
2008-06-06