25 新β-ラクトン抗生物質オキサゾロマイシンの構造

概要

論文の詳細を見る
Oxazolomycin is a new antitumor antibiotic isolated from Streptomyces sp. (Y-32026). The structural elucidation of this non-crystalline antibiotic has been carried out. Its structure has been determined as shown in 1 on the basis of spectral analysis, X-ray crystallographic analysis or synthesis of corresponding degraded products. Our interests have been focused on not only its novel structure exemplified as the β-lactone functional groupings but also the structure-activity relationship. Therefore, in vitro direct cytotoxicity of oxazole derivatives and each segment of oxazolomycin has been examined. Based on some obtained results, the structure-activity relationship of oxazolomycin will be discussed. Isolation and strcutures of two minor congeners will be also reported.
天然有機化合物討論会の論文
1983-09-15