8 新規貝毒Pinnatoxin類の構造研究(口頭発表の部)

概要

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Our continuing interest in marine toxins such as palytoxin focused on the structure determination of the potent shellfish poison, pinnatoxins which was recently reported as a Ca^<2+> channel activator by Chinese inverstigators. We isolated two new toxins, named pinnatoxin A (1), B, C (2) and one congener pinnatoxin D (3) from the 75% MeOH extracts of the Okinawan Pinna muricata. Espesially, the toxicity of pinnatoxin B, C (2) is as significant as that of tetrodotoxin. Molecular fomulas of (1), (2) and (3) were deduced to be C_<41>H_<61>NO_9. C_<42>H_<63>NO_<10> and C_<45>H_<67>NO_<10> from HRFABMS spectra and NMR spectra data respectively. Their planar structures were determined mainly by interpretation of 2D NMR (DQF-COSY, HOHAHA, HSQC-HOHAHA, HMBC) spectra to be a macrocyclic polyether including carboxylate and iminium functionality. The relative stereochemistry was proposed by the detailed analysis of the NOESY, ROESY data.
天然有機化合物討論会の論文
1994-09-20