Biochemical Mechanism of C-P Bond Formation of Bialaphos : Use of Gene Manipulation for the Analysis of the C-P Bond Formation Step(Biological Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
One of the three C-P bond formation steps, defined as step 5 in the bialaphos (BA) biosynthetic pathway, was analyzed using a new BA non-producing mutant NP71. The mutant was derived from a BA producer by gene replacement of an unidentified region next to the gene responsible for the step 5 deficiency of the mutant NP213, obtained by conventional mutation procedures. Biochemical analysis of these two mutants indicated that NP71 was defective in the formation of carboxyphosphonoenolpyruvate (CPEP), while NP213 lacked the enzyme CPEP phosphonomutase, which catalyzed the intramolecular rearrangement of CPEP.
- 社団法人日本農芸化学会の論文
- 1990-08-23
著者
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IMAI Satoshi
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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Seto H
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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Imai S
Nara Prefectural Inst. Public Health Nara Jpn
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Nagaoka Kozo
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Hidaka T
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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Hidaka Tomomi
Institute Of Applied Microbiology The University Of Tokyo
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Hara O
Chiba Univ. Chiba Jpn
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Hara Osamu
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Seto Haruo
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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Muro Tetsuo
Osaka Municipal Technical Research lnstitute
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ANZAI Hiroyuki
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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MURAKAMI Takeshi
Pharmaceutical Technology Laboratory, Meiji Seika Kaisha, Ltd.
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Seto Haruo
Institute Of Applied Microbiology The University Of Tokyo
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Anzai Hiroyuki
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Murakami T
Process Research Laboratory Meiji Seika Kaisha Ltd.
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NAGAOKA Kozo
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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HARA Osamu
Pharmaceutical Research Center, MeijiSeika Kaisha Ltd.
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HARA Osamu
Department of Physics and Atomic Energy Research Institute, Nihon University
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IMAI Satoshi
Pharmaceutical Development Laboratories, Meiji Seiko Kaisha Ltd.
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