Purification and Characterization of Citrate Synthase from Streptomyces hygroscopicus SF-1293 and Comparison of Its Properties with Those of 2-Phosphinomethylmalic Acid Synthase(Biological Chemistry)
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概要
- 論文の詳細を見る
To study the relationship between citrate synthase and 2-phosphinomethylmalic acid(PMM) synthase, which catalyzes a very similar reaction comparable to citrate formation in the biosynthesis of a herbicide, bialaphos, citrate synthase was purified from the mycelium of Streptomyces hygroscopicus SF-1293, a bialaphos-producing organism. The overall purification was 440-fold with a yield of 4.4% from cell-free extract. Based on comparison with PMM synthase, it has been concluded that citrate synthase of S. hygroscopicus is quite different from PMM synthase in several aspects such as enzymatic properties, amino acid composition, N-terminal amino acid sequence, and stereo-chemical reaction mechanism.
- 社団法人日本農芸化学会の論文
- 1990-02-23
著者
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Shimotohno Kumiko-W.
Kyoritsu College of Pharmacy
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Seto H
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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Imai S
Nara Prefectural Inst. Public Health Nara Jpn
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Seto Haruo
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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Muro Tetsuo
Osaka Municipal Technical Research lnstitute
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SHIMOTOHNO Kumiko
Institute of Applied Microbiology, The University of Tokyo
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IMAI Satoshi
Process Research Laboratory, Meiji Seika Kaisha, Ltd.
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MURAKAMI Takeshi
Process Research Laboratory, Meiji Seika Kaisha, Ltd.
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Shimotohno Kumiko
Institute Of Applied Microbiology The University Of Tokyo
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Seto Haruo
Institute Of Applied Microbiology The University Of Tokyo
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Murakami T
Process Research Laboratory Meiji Seika Kaisha Ltd.
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