正常および硬化した大動脈中の糖タンパク質の比較検討

概要

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Human aortas were classified into five groups according to the degree of atherosclerosis (Gore's criteria) of Normal, Grade 1, Grade 2, Grade 3 and Grade 4. Homogenized aorta of each group was analyzed for carbohydrates and sulfate. The content of sulfate was significantly increased to a high degree in atherosclerosis, while the content of hexosaimne and hexuronic acid were decreased. Crude carbohydrate-protein complexes were extracted from the Normal and Grade 3 aorta by the phenol method. Extracts of Normal and Grade 3 types were analyzed and further fractionated by DEAE-cellulose column chromatography. The chromatographic patterns and the chemical and electrophoretic analyses of each fraction of the Normal and Grade 3 types indicate that there are marked differences between the carbohydrate-protein complexes in the Normal and Grade 3 aorta.
北里大学の論文
1975-02-28