Studies on the Syntheses of 2 (1H)-Pyridone Derivatives. II. Reactions of N-Substituted 6-Chloro-2 (1H)-pyridones with Ethylenediamine, 2-Aminoethanethiol and Related Compounds
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概要
- 論文の詳細を見る
It has been found that Smiles rearrangement leading to N-p-chlorophenyl-6-β-hydroxyethylamino-4-phenyl-2 (1H)-pyridone (II) took place when 6-β-aminoethoxy-N-p-chlorophenyl-4-phenyl-2 (1H)-pyridone (III) was heated in acetic acid, and that the reaction of an N-substituted 6-chloro-4-phenyl-2 (1H)-pyridone (I) with ethylenediamine, 2-amino-ethanethiol or o-aminothiophenol gives condensed heterocyclic pyridones such as imidazopyridone (IV), thiazolopyridone (X) or benzothiazolopyridone (XV). This reaction is considered to proceed by ring transformation of an intermediate of the Smiles rearrangement. Some of these pyridone derivatives showed strong biological activities as analgesic and antiinflammatory agents.
- 公益社団法人日本薬学会の論文
- 1979-05-25
著者
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村上 増雄
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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磯村 八州男
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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伊藤 徳樹
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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本間 弘茂
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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久保 一夫
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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久保 一夫
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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磯村 八州男
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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僧都 勲
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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伊藤 徳樹
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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磯村 八州男
山之内製薬
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本間 弘茂
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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僧都 勲
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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