METABOLIC CONVERSION OF CYCLOCARBO-THIAMINE INTO THIAMINE
スポンサーリンク
概要
- 論文の詳細を見る
Metabolic conversion of cyclocarbothiamine into thiamine was studied in vivo as well as in vitro.1. The compound was easily transformed into thiamine when incubated with rabbit blood.The supernatant obtained from liver and kidney homogenate of rats also changed cyclocarbothiamine into thiamine. No such conversion occurred with heated supernatant.2. Manometric measurement of carbon dioxide liberated during the conversion showed that it was produced in an amount equimolar to thiamine.3. Bioautography with Lactobacillus fermenti revealed that not a trace of cyclocarbothiamine remained unchanged in blood samples taken 30 minutes after oral or intravenous administration to rabbits. Nor was it detected as such in urine.However, a trace amount of the compound was detected unaltered in threehour urine samples following oral administration of 50mg to human subjects.4. The following metabolic schema has been established.Cyclocarbothiamine → Thiamine+CO2
- 日本ビタミン学会の論文
著者
-
村上 増雄
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
-
塩原 有一
Ceutral Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
-
塩原 有一
Central Research Laboratory, Yamanouchi Pharmaceutical Company
-
佐藤 登
Central Research Laboratory, Yamanouchi Pharmaceutical Company
-
与儀 啓子
Central Research Laboratory, Yamanouchi Pharmaceutical Company
関連論文
- An Improved Synthesis of Pyrimido [5,4-d] pyrimidine Derivatives substituted by Mercapto Groups
- Synthesis of 2-N, N-Dialkylamino-1-aroyloxybenzocycloalkanes
- Synthesis of New Water-soluble Dihydropyridine Vasodilators
- Absolute Configurations of Four Isomers of 3-Formamido-4-hydroxy-α-[[N-(p-methoxy-α-methylphenethyl) amino] methyl] benzyl Alcohol, a Potent β-Adrenoreceptor Stimulant
- New β-Adrenoreceptor Stimulants. Studies on 3-Acylamino-4-hydroxy-α-(N-substituted aminomethyl) benzyl Alcohols
- Unambiguous Synthesis of 1-(7-Indenyloxy)-3-isopropylamino-2-propanol Hydrochloride and Its 4-Indenyloxy Isomer, Potent β-Adrenergic Blocking Agents
- Lactol Esters of Ampicillin
- Studies on Prostaglandins. I. The Resolution of dl-(2β-Benzyloxymethyl-3α-hydroxy-4-cyclopenten-1α-yl) acetic Acid using L-Arginine
- 11.Cyclocarbothiamineの腸管にたいする作用とその体内分布(第193回会議研究発表要旨)
- Cyclocarbothiamineにかんする研究(VIII)マウスに静脈内注射したときの分布および排泄について
- 111.Hydroxyethylthiamineにかんする研究(III) : Hydroxyalkylthiamineの2,3の化学的ならびに生物学的性質(日本ビタミン学会第17回大会研究発表要旨)
- Studies on Condensed Heterocyclic Isoquinolone Derivatives. III. A Novel Oxidative Rearrangement of 11-Methyl-6-oxo-3,4-dihydro-2H, 6H-1,3-thiazino [3,2-b] isoquinoline
- Studies on the Synthesis of Condensed Heterocyclic Isoquinolone Derivatives. I. Studies on the Synthesis and Pharmacology of Thiazino, Oxazino and Pyrimido Isoquinolones
- Studies on the Syntheses of 2 (1H)-Pyridone Derivatives. II. Reactions of N-Substituted 6-Chloro-2 (1H)-pyridones with Ethylenediamine, 2-Aminoethanethiol and Related Compounds
- Studies on Prostaglandins. VI. Synthesis of 16 (S)-Methyl-20-methoxy-PGE_2 (YPG-209) having Oral Bronchodilator Activity and Its Analogs
- Studies on Prostaglandins. II. Synthesis of 4-Alkoxymethyl-2-norbornen-5-one and Its Oxidation Reaction with m-Chloroperbenzoic Acid
- Studies on Prostaglandins. III. Synthesis of Bicyclo [4. 3. 0] nonane Derivatives
- A Novel Synthesis of α-Halo Carbonyl Compounds using Metal Halides
- Studies on Morphinan Derivatives. II. The Synthesis of d-3-Methyl-N-methylmorphinan, a New Antitussive
- Cyclocarbothiamineにかんする研究 : (I)Cyclocarbothiamineの生物学的性質
- An Improved Synthesis of Metoclopramide
- Synthesis of the Metabolites of 2-(N-Benzyl-N-methylamino)ethyl Methyl 2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride (Nicardipine Hydrochloride, YC-93)
- Synthesis of Optically Active 2-(N-Benzyl-N-methylamino)ethyl Methyl 2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (Nicardipine)
- Studies on Morphinan Derivatives. I. The Synthesis of Several New 3-Substituted Derivatives of N-Methylmorphinan having Antitussive Activities
- Cyclocarbothiamineにかんする研究 : (VI)Cyclocarbothiamineの腸管吸収過程における挙動について
- METABOLIC CONVERSION OF CYCLOCARBO-THIAMINE INTO THIAMINE
- STUDIES ON HYDROXYETHYLTHIAMINE AND RELATED COMPOUNDS : III. NATURE OF THIAMINE-ACTIVE COMPOUNDS IN THE LIVER FOLLOWING ORAL ADMINISTRATION OF HYDRO-XYALKYLTHIAMINE TO THIAMINE-DEFICIENT RATS
- BIOLOGICAL PROPERTIES OF A NEW THIAMINE DERIVATIVE, CYCLOCARBOTHIAMINE
- STUDIES ON THE REACTION OF THIAMINE WITH PHOSGENE
- The Synthesis of Pyridoxine Derivatives:II. The Synthesis of Pyridoxine Disulfide and Pyridoxamine Disulfide
- STUDIES ON HYDROXYETHYLTHIAMINE AND RELATED COMPOUNDS:I. VITAMIN B1 ACTIVITY OF HYDROXYALKYLTHIAMINE
- The Synthesis of Pyridoxine Derivatives:I. The Synthesis of Pyridoxylthiamine Disulfide