Synthesis of Optically Active 2-(N-Benzyl-N-methylamino)ethyl Methyl 2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (Nicardipine)
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概要
- 論文の詳細を見る
(+)- and (-)-2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (6) (nicardipine) were synthesized from (-)- and (+)- 1-ethoxymethyl-5-methoxycarbonyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (3), respectively. Resolution of 3 was carried out using cinchonidine and cinchonine as resolving agents. The vertebral vasodilating activity of (+)-YC-93 (the hydrochloride of (+)-(6)) was about 3 times that of (-)-YC-93.
- 公益社団法人日本薬学会の論文
- 1980-09-25
著者
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村上 増雄
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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岩波 勝
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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柴沼 忠夫
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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竹中 登一
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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柴沼 忠夫
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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奥田 幸平
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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竹中 登一
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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岩波 勝
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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奥田 幸平
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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