STUDIES ON THE REACTION OF THIAMINE WITH PHOSGENE
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概要
- 論文の詳細を見る
Depending upon the reaction temperature, the reaction of thiamine with phosgene in an alkaline solution gave rise to two different compounds as follows. At 0-5°, N-[1-(2-oxo-1, 3-oxathian-4-ylidene) ethyl]-N-[(4-amino-2-methyl-5-pyrimidinyl) methyl] formamide (V) and at -20°, bis-2-[N-(4-amino-2-methyl-5-pyrimidinylmethyl) formamido]-1-(2-hydroxyethyl) propenthiol carbonate (XVI). The structure of XVI and V were confirmed by several methods. Thermal decomposition of V was also studied. These new compounds showed thiamine-activity, and V is particularly remarkable among them, since it was quite readily absorbable from the intestine.
- 日本ビタミン学会の論文
著者
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村上 増雄
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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平田 康文
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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岩本 英徳
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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高橋 孝三
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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高橋 孝三
Central Research Laboratory, Yamanouchi Pharmaceutical Co., Ltd.
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村上 増雄
Central Research Laboratory, Yamanouchi Pharmaceutical Co., Ltd.
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平田 康文
Central Research Laboratory, Yamanouchi Pharmaceutical Co., Ltd.
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岩本 英徳
Central Research Laboratory, Yamanouchi Pharmaceutical Co., Ltd.
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