Studies on Prostaglandins. VI. Synthesis of 16 (S)-Methyl-20-methoxy-PGE_2 (YPG-209) having Oral Bronchodilator Activity and Its Analogs
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概要
- 論文の詳細を見る
16 (S)-Methyl-20-methoxy-PGE_2 (YPG-209) (Is), 16 (R)-methyl-20-methoxy-PGE_2 (I_R) and several analogs, such as 16 (S)-methyl-20-methoxy-PGA_2 (XIIIs) and -PGB_2 (XIVs), 16-methyl-20-ethoxy-PGE_2 (XXVIIa), 16-methyl-20-hydroxymethyl-PGE_2 (XXVIa), 16-methyl-17-oxa-ω-dihomo-PGE_2 (XXVIIIa) and 20-hydroxymethyl-PGE_2 (XXX), were synthesized by Corey's procedure and their biological activities were investigated. Among these derivatives, I_S and I_R possessed potent oral bronchodilator activity ; the bronchoselectivity of I_S was higher than that of I_R.
- 公益社団法人日本薬学会の論文
- 1980-05-25
著者
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犬飼 紀喜
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,
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石井 吉雄
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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村上 増雄
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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柳沢 勲
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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柳沢 勲
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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柳沢 勲
山之内製薬株式会社創薬研究本部
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田村 隼也
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,
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石井 吉雄
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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岩本 英徳
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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田村 隼也
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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田村 隼也
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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岩本 英徳
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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塩崎 哲也
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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高木 徳一
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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富岡 健一
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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富岡 健一
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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犬飼 紀喜
Tsukuba Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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高木 徳一
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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塩崎 哲也
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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