Studies on Prostaglandins. III. Synthesis of Bicyclo [4. 3. 0] nonane Derivatives

スポンサーリンク

概要

• 論文の詳細を見る

• 3-(4-Carboxybutylidene)-7α, 9α-dihydroxy-4-hexyl-1βH, 6αH-bicyclo [4.3.0] nonane (III) and 3-(4-carboxybutylidene)-7α, 9α-dihydroxy-4-(1-hydroxyhexyl)-1βH, 6αH-bicyclo [4.3.0]-nonane (IV) were synthesized as prostaglandin-derivatives which were related to steroids. Preliminary in vitro studies on isolated guinea pig ileum have shown that IV possessed weakly PG-like contraction activity (1/300 of PGF_<2α>) and III did not possess the PG-like activity.

• 公益社団法人日本薬学会の論文
• 1976-06-25

著者

• 犬飼 紀喜

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,

• 石井 吉雄

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 村上 増雄

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 柳沢 勲

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 柳沢 勲

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 柳沢 勲

  山之内製薬株式会社創薬研究本部

• 田村 隼也

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.,

• 石井 吉雄

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 岩本 英徳

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 田村 隼也

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 田村 隼也

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• 岩本 英徳

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 高木 徳一

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 富岡 健一

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 富岡 健一

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 犬飼 紀喜

  Tsukuba Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 高木 徳一

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

関連論文

• ヒスタミン H_2 受容体拮抗薬, ファモチジン/ガスター(日本で生まれた医薬品)
• Studies on Amino Acid Derivatives. IX. : Synthesis of Chiral Penam-3-carboxylic Acid and Its Substituted Derivatives
• An Improved Synthesis of Pyrimido [5,4-d] pyrimidine Derivatives substituted by Mercapto Groups
• Synthesis of 2-N, N-Dialkylamino-1-aroyloxybenzocycloalkanes
• Synthesis and Structure-Activity Studies of a Series of 1-Oxa-2,8-diazaspiro[4.5]decan-3-ones and Related Compounds as M_1 Muscarinic Agonists
• Synthesis of New Water-soluble Dihydropyridine Vasodilators
• Absolute Configurations of Four Isomers of 3-Formamido-4-hydroxy-α-[[N-(p-methoxy-α-methylphenethyl) amino] methyl] benzyl Alcohol, a Potent β-Adrenoreceptor Stimulant
• 2-Amino-1-benzocycloalkanol誘導体の立体化学2-Acylamino-1-benzocycloalkanolと塩化チオニルならびに濃硫酸との反応
• New β-Adrenoreceptor Stimulants. Studies on 3-Acylamino-4-hydroxy-α-(N-substituted aminomethyl) benzyl Alcohols
• Lactol Esters of Ampicillin
• 5.アルキルコバラミンの合成(II)(第171回会議研究発表要旨)
• 15.アルキルコバラミンの合成(第170回会議研究発表要旨)
• ビタミンB_1とホスゲンの反応
• 15.ビタミンB_1とホスゲンとの反応(第162回会議研究発表要旨)
• Synthesis of 1,3-Dioxin-4-ones and Their Use in Synthesis XX. : (6S, 7S, 10R)- and (6R, 7S, 10R)-7-Isopropyl-10-mythyl-4-oxo-1,5-dioxaspiro[5.5]undec-2-enes; Synthesis and Their Use in Enantiomerically Pure Corey Lactone Analogue Synthesis
• 含硫黄ピリミド[5,4-d]ピリミジン化合物の合成研究(第3報)Dipyridamoleの新合成法
• Studies on Prostaglandins. I. The Resolution of dl-(2β-Benzyloxymethyl-3α-hydroxy-4-cyclopenten-1α-yl) acetic Acid using L-Arginine
• Studies on Condensed Heterocyclic Isoquinolone Derivatives. III. A Novel Oxidative Rearrangement of 11-Methyl-6-oxo-3,4-dihydro-2H, 6H-1,3-thiazino [3,2-b] isoquinoline
• Studies on the Synthesis of Condensed Heterocyclic Isoquinolone Derivatives. I. Studies on the Synthesis and Pharmacology of Thiazino, Oxazino and Pyrimido Isoquinolones
• Studies on the Syntheses of 2 (1H)-Pyridone Derivatives. II. Reactions of N-Substituted 6-Chloro-2 (1H)-pyridones with Ethylenediamine, 2-Aminoethanethiol and Related Compounds
• Studies on Prostaglandins. VI. Synthesis of 16 (S)-Methyl-20-methoxy-PGE_2 (YPG-209) having Oral Bronchodilator Activity and Its Analogs
• Studies on Prostaglandins. II. Synthesis of 4-Alkoxymethyl-2-norbornen-5-one and Its Oxidation Reaction with m-Chloroperbenzoic Acid
• Studies on Prostaglandins. III. Synthesis of Bicyclo [4. 3. 0] nonane Derivatives
• A Novel Synthesis of α-Halo Carbonyl Compounds using Metal Halides
• Studies on Morphinan Derivatives. II. The Synthesis of d-3-Methyl-N-methylmorphinan, a New Antitussive
• An Improved Synthesis of Metoclopramide
• Mild Dehalogenative Reduction of Tri- and Di-halogenomethyl Compounds to Lower Halides by Nickel Tetracarbonyl
• Synthesis of the Metabolites of 2-(N-Benzyl-N-methylamino)ethyl Methyl 2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride (Nicardipine Hydrochloride, YC-93)
• Synthesis of Optically Active 2-(N-Benzyl-N-methylamino)ethyl Methyl 2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (Nicardipine)
• 110 ヒスタミンH_2受容体遮断薬ガスターの研究開発
• 創薬研究における有機合成化学者の役割
• Studies on Morphinan Derivatives. I. The Synthesis of Several New 3-Substituted Derivatives of N-Methylmorphinan having Antitussive Activities
• METABOLIC CONVERSION OF CYCLOCARBO-THIAMINE INTO THIAMINE
• STUDIES ON HYDROXYETHYLTHIAMINE AND RELATED COMPOUNDS : III. NATURE OF THIAMINE-ACTIVE COMPOUNDS IN THE LIVER FOLLOWING ORAL ADMINISTRATION OF HYDRO-XYALKYLTHIAMINE TO THIAMINE-DEFICIENT RATS
• BIOLOGICAL PROPERTIES OF A NEW THIAMINE DERIVATIVE, CYCLOCARBOTHIAMINE
• STUDIES ON THE REACTION OF THIAMINE WITH PHOSGENE
• The Synthesis of Pyridoxine Derivatives:II. The Synthesis of Pyridoxine Disulfide and Pyridoxamine Disulfide
• STUDIES ON HYDROXYETHYLTHIAMINE AND RELATED COMPOUNDS:I. VITAMIN B1 ACTIVITY OF HYDROXYALKYLTHIAMINE
• The Synthesis of Pyridoxine Derivatives:I. The Synthesis of Pyridoxylthiamine Disulfide

もっと見る 閉じる

スポンサーリンク