Lactol Esters of Ampicillin

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概要

• 論文の詳細を見る

• Several lactol esters of D-α-aminobenzylpenicillin hydrochloride (Va-e) were synthesized from the corresponding lactol esters of benzylpenicillin (IIa-e) or from D-α-aminobenzylpenicillin (ampicillin). The lactol esters IIa-e were prepared with potassium benzylpenicillinate (I) and certain halides of lactols. Among them, two isomers of 2 (5H)-furanone-5-yl benzylpenicillinate (IIb) could be easily separated from the mixture of the stereoisomers due to C_5' position of the lactol moiety. We found that all of these lactol esters of ampicillin hydrochloride (Va-e) showed higher blood concentrations of ampicillin after oral administration to rats than that of ampicillin itself. Particularly Va and Ve were much superior.

• 公益社団法人日本薬学会の論文
• 1976-01-25

著者

• 高橋 孝三

  山之内製薬中央研究所

• 村上 増雄

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 高橋 孝三

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 伊坂 一郎

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 中野 功二

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 柏木 輝也

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 甲田 彰男

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 堀口 宏

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 松井 秀文

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 堀口 宏

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 松井 秀文

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 甲田 彰男

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 高橋 孝三

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 伊坂 一郎

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 中野 功二

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 柏木 輝也

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

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