Synthesis of 2-N, N-Dialkylamino-1-aroyloxybenzocycloalkanes
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概要
- 論文の詳細を見る
Aroyl esters of 2-N, N-dialkylamino-1-benzocycloalkanols (6,7), which may be considered to be semi-rigid cyclic analogs of procaine, were prepared to study the influence of the stereochemical relationship between the aroyloxy and the amino group on local anesthetic activity. The cis-compounds (6a-1,6c-1) were more active than the corresponding trans-isomers (6b-1,6d-1). Similarly, the optical isomers of cis-2-N, N-dimethylamino-1-benzoyloxy-1,2,3,4-tetrahydronaphthalene (6c-1) differed in their activity with the l-isomer being more active. The reaction of 2-bromo-1-tetralol (9) with dimethylamine was also discussed.
- 社団法人日本薬学会の論文
- 1977-05-25
著者
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高橋 孝三
山之内製薬中央研究所
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竹田 正明
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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村上 増雄
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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高橋 孝三
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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平田 康文
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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柳沢 勲
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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井野 浩喜
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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平田 康文
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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柳沢 勲
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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柳沢 勲
山之内製薬株式会社創薬研究本部
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高橋 孝三
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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井野 浩喜
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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