Studies on Novel Bone Resorption Inhibitors. I. Synthesis and Pharmacological Activities of Aminomethylenebisphosphonate Derivatives
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概要
- 論文の詳細を見る
A series of aminomethylenebisphosphonate derivatives was synthesized and evaluated for their antiresorptive activities using a parathyroid hormone (PTH)-induced hypercalemia model in rats (PIH model). Among these compounds, (cycloheptylamino)methylenebis(phosphonic acid) (3j) was finally selected for further investigation, proving 10-fold as potent as pamidronate in the PIH model and an immobilization bone atrophy model in rats (DA model). The structure-activity relationships of this series of bisphosphonates are discussed.
- 公益社団法人日本薬学会の論文
- 1993-04-15
著者
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坂本 修一
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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阿部 哲士
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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吉田 誠
Patent Department Yamanouchi Pharmaceutical Co. Ltd.
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竹内 誠
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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磯村 八州男
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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磯村 八州男
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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竹内 誠
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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