Studies on the Synthesis and Anti-Inflammatory Activity of 2,6-Di-tert-butylphenols with a Heterocyclic Group at the 4-Position. I
スポンサーリンク
概要
- 論文の詳細を見る
A number of 2,6-di-tert-butylphenols with a heterocyclic group at the 4-position were prepared. The heterocyclic groups were as follows : benzoxazole, benzothiazole, benzimidazole, indole, imidazo [1,2-a] pyridine and imidazo [1,2-a] pyrimidine. Anti-inflammatory activity of these compounds was examined by using the adjuvant-induced arthritis (A. A) assay. Some compounds were further tested in carrageenin-induced rat paw edema (CIPE) assay and AcOH-induced writhing (AIW) assay in mice. The anti-inflammatory activity was greatly dependent on the value of the heterocyclic group. Among these compounds, 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-benzoxazole (IIa) and 2-(3,5-di-tert-butyl-4-hydroxyphenyl) indole (Xg) showed very potent activity. Both IIa and Xg had a minimum effective dose of 5 mg/kg (p. o.) in A. A assay and showed stronger activity than phenylbutazone in CIPE assay but weaker analgesic activity than aminopyrine in AIW assay.
- 公益社団法人日本薬学会の論文
- 1983-09-25
著者
-
阿部 哲士
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
-
伊藤 徳樹
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
-
本間 弘茂
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
-
久保 一夫
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
-
久保 一夫
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
-
伊藤 徳樹
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
-
磯村 八州男
山之内製薬
-
本間 弘茂
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
関連論文
- 2-Amino-1-benzocycloalkanol誘導体の立体化学2-Acylamino-1-benzocycloalkanolと塩化チオニルならびに濃硫酸との反応
- Studies on Novel Bone Resorption Inhibitors. I. Synthesis and Pharmacological Activities of Aminomethylenebisphosphonate Derivatives
- Synthesis and Anti-inflammatory Activity of 2,6-Di-tert-butylphenols with a Heterocyclic Group at the 4-Position. III.
- Studies on the Synthesis and Anti-Inflammatory Activity of 2,6-Di-tert-butylphenols with a Heterocyclic Group at the 4-Position. II
- Studies on the Synthesis and Anti-Inflammatory Activity of 2,6-Di-tert-butylphenols with a Heterocyclic Group at the 4-Position. I
- 4位複素環を有する2,6-Di-tert-butylphenolsの合成と抗炎症作用に関する研究(第4報)4-(3,5-Di-tert-butyl-4-hydroxyphenyl)-2-oxo-4-imidazolinesの光酸素酸化および塩基触媒酸素酸化反応
- Studies on Condensed Heterocyclic Isoquinolone Derivatives. III. A Novel Oxidative Rearrangement of 11-Methyl-6-oxo-3,4-dihydro-2H, 6H-1,3-thiazino [3,2-b] isoquinoline
- ヘテロ環縮合Isoquinolone誘導体の合成研究(第2報)Thiazinoisoquinolone誘導体の合成と薬理作用
- Studies on the Synthesis of Condensed Heterocyclic Isoquinolone Derivatives. I. Studies on the Synthesis and Pharmacology of Thiazino, Oxazino and Pyrimido Isoquinolones
- 2(1H)-Pyridone誘導体の合成研究(第4報)ヘテロ環縮合2(1H)-Pyridoneの合成
- 2(1H)-Pyridone誘導体の合成研究(第3報)6-Amino-2(1H)-pyridone誘導体の合成とその閉環反応
- 2(1H)-Pyridone誘導体の合成研究(第1報)6-置換2(1H)-Pyridoneの合成と薬理作用
- Studies on the Syntheses of 2 (1H)-Pyridone Derivatives. II. Reactions of N-Substituted 6-Chloro-2 (1H)-pyridones with Ethylenediamine, 2-Aminoethanethiol and Related Compounds
- Cyclocarbothiamineにかんする研究 : (I)Cyclocarbothiamineの生物学的性質
- Studies on the Synthesis and Anti-inflammatory Activity of 2,6-Di-tert-butylphenols with a Heterocyclic Group at the 4-Position. V. Elimination Reaction of the Sulfinyl Group of 2,3-Dihydroimidazo [2,1-b] thiazole 1-Oxide
- アロマターゼ阻害薬の研究開発動向
- Biotinの合成研究(第3報) : 3,4-(1', 3'-Dibenzyl-2'-oxoimidazolido)-2-oxothiophaneのGrignard反応
- Biotinの合成研究(第2報) : 3,4-(1', 3'-Dibenzyl-2'-oxoimidazolido)-2-Oxothiophaneの合成
- Biotinの合成研究(第4報) : 1,4-Butylenedimagnesium HalideのGrignard反応によるBiotinの新合成法
- Biotinの合成研究(第1報) : 4,5-二置換4-imidazolin-2-one類の接触還元
- 3,4-Diaminochromanの立体化学
- BIOLOGICAL PROPERTIES OF A NEW THIAMINE DERIVATIVE, CYCLOCARBOTHIAMINE
- STUDIES ON HYDROXYETHYLTHIAMINE AND RELATED COMPOUNDS:I. VITAMIN B1 ACTIVITY OF HYDROXYALKYLTHIAMINE