4位複素環を有する2,6-Di-tert-butylphenolsの合成と抗炎症作用に関する研究(第4報)4-(3,5-Di-tert-butyl-4-hydroxyphenyl)-2-oxo-4-imidazolinesの光酸素酸化および塩基触媒酸素酸化反応
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概要
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Photo-oxygenation of 4-(3,5-di-tert-butyl-4-hydroxyphenyl)-5-methyl-2-oxo-4-imidazoline (1b) gave 2,6-di-tert-butyl-p-benzoquinone (2), N-acetyl-N'-(3,5-di-tert-butyl-4-hydroxybenzoyl) urea (3) and 4-(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadien-1-ylidene)-5-methoxy-5-methyl-2-oxo-imidazoline (4b), and 4b was the main product. Base-catalyzed oxygenation of 1b and related derivatives was carried out. Base-catalyzed oxygenation of 1b also gave 2,N-(3,5-di-tert-butyl-4-hydroxybenzoyl) urea (5) and 4b. The mechanism of the reaction between 1b and oxygen giving compounds 2,3,4b and 5 was proposed.
- 公益社団法人日本薬学会の論文
- 1984-08-25
著者
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坂本 修一
Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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久保 一夫
山之内製薬株式会社中央研究所
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久保 一夫
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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坂本 修一
山之内製薬株式会社中央研究所
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磯村 八州男
山之内製薬
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