Synthesis of α- and γ-(N-Carbobenzoxy-and N-tert-Butyloxycarbonyl-L-Glutamyl) cholines
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概要
- 論文の詳細を見る
In order to examine the lipotropic and hypotensive effects of glutamylcholines, α-and γ-(Z-and Boc-glutamyl) cholines (4a, 4'a, 4b and 4'b) were synthesized by the removal of the tert-butyl and benzyl groups of the corresponding tert-butyl (3a and 3'a) and benzyl (3b and 3'b) choline esters which were obtained by the esterification of tert-butyl Z-glutamates (1a and 1'a) and benzyl Boc-glutamate dicyclohexylamine salts (1b and 1'b) with N, N-dimethylaminoethyl chloride, followed by methylation with methyl halide.
- 公益社団法人日本薬学会の論文
- 1985-11-25
著者
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枡井 雅一郎
Faculty Of Pharmaceutical Sciences Osaka University
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金岡 又雄
富山医科薬科大学医学部
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金岡 又雄
Research Institute for WAKAN-YAKU (Oriental Medicines), Toyama Medical and Pharmaceutical University
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堀川 裕司
Sanei Kagaku Kogyo Co., Ltd.
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枡井 雅一郎
Bio-Medical Research Laboratory, Morinaga Milk Industry, Co., Ltd.
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西澤 義人
Bio-Medical Research Laboratory, Morinaga Milk Industry, Co., Ltd.
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西澤 義人
Bio-medical Research Laboratory Morinaga Milk Industry Co. Ltd.
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堀川 裕司
Sanei Kagaku Kogyo Co. Ltd.
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金岡 又雄
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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枡井 雅一郎
大阪大学薬学部
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