Chemical Studies on Amino Acids and Peptides. III. 4,5-Diaryl-4-oxazolin-2-one Derivatives as an Amino Protecting Group
スポンサーリンク
概要
- 論文の詳細を見る
4,5-Diaryl-4-oxazolin-2-one [V : R=CH_3O (AOX) and R=Cl (COX)] derivatives of amino acids were prepared by condensation of 4,5-diaryl-1,3-dioxol-2-one (III : R=CH_3O and R=Cl) with amino acids. These oxazolinone derivatives were stable to NaOH-aq. EtOH and liquid hydrogen fluoride at room temperature, but were cleaved by hydrogenolysis over pd-carbon. Pentagastrin protected with AOX group, AOX-Gly-Trp-Met-Asp-Phe-NH_2,was prepared and its biological effect was examined on gastric secretion in young chicken.
- 公益社団法人日本薬学会の論文
- 1978-02-25
著者
-
倉田 裕司
Research Institute For Wakan-yaku University Of Toyama
-
金岡 又雄
Research Institute for WAKAN-YAKU (Oriental Medicines), Toyama Medical and Pharmaceutical University
-
金岡 又雄
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
関連論文
- Studies on the Enzyme Immunoassay of Bio-Active Constituents Contained in Oriental Medicinal Drugs. III. Enzyme Immunoassay of Paeoniflorin, a Constituent of Chinese Paeony Root
- Synthesis of α- and γ-(N-Carbobenzoxy-and N-tert-Butyloxycarbonyl-L-Glutamyl) cholines
- Studies on the Enzyme Immunoassay of Bio-active Constituents Contained in Oriental Medicinal Drugs. II. Enzyme Immunoassay of Glycyrrhizin
- Glycyrrhetylamino Acids : Synthesis and Application to Enzyme Immunoassay for Glycyrrhetic Acid
- Studies on the Constituents of Trichosanthes Species. I. On the Neutral Ether Extracts of the Dried Roots of Trichosanthes japonica REGEL, Trichosanthes kirilowii MAXIM. and Trichosanthes cucumeroides MAXIM.
- Chemical Studies on Amino Acids and Peptides. II. Syntheses of Choline Esters of Peptides related to Tetragastrin
- Chemical Studies on Amino Acids and Peptides. III. 4,5-Diaryl-4-oxazolin-2-one Derivatives as an Amino Protecting Group
- Synthesis of Related Compounds of Thiosemi-carbazide. IV. 1-(1,3,4-Thiadiazol-2-yl)-2-pyrazolin-5-one and Tetrazolo [4,5-a]-1,3,4-thiadiazole Derivatives.