原子吸光分析法によるバルビツール酸類の間接定量

概要

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Barbituric acid derivatives such as barbital, amobarbital, allylisobutylbarbital, phenobarbital, allobarbital, pentobarbital, and ethylhexabarbital were indirectly determined with good precision by atomic absorption spectrophotometry (A. A. S.). The recommended procedures are as follows. To 1 ml of methanol solution of each sample {(10〜240) *g/ml is added with 1ml of methanol solution of copper sulfate (1.40 mg/ml) and 0.5 ml of diethylamine, and then brought to 10ml with methanol. The mixture is allowed to stand for 30 min and then filtered. The copper content of the nitrate is measured by A. A. S. No detectable interference for determination of barbiturates occured with any of the other compounds, such as sulfonal, bromovalerylurea, bromodiethylacetylurea, ethinamate, and glutethimide. Various metal ions, such as Na^+ , N^<2+>, Co^<2+>, Zn^<2+>, K^+, and Fe^<3+> interfered with the determination of barbiturates. The interferences of these ions were eliminated by extraction of barbiturates with chloroform.
社団法人日本分析化学会の論文
1982-10-05