血液中からのメタンフェタミンの抽出時における無機吸着剤セライト545を用いた妨害物質の除去

概要

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Celite 545, an adsorbent, was applied to the extraction of methamphetamine from human blood. Interfering compounds on the determination of methamphetamine could be eliminated by adding celite 545. The experimental procedure is as follows : In a 15 ml test tube, place 1 ml of human blood containing less than 200 μg of methamphetamine, 0.5 ml of saturated sodium carbonate, and 0.2 g of celite 545. Shake the solution for 30 s and stand for 7 min. Add 5 ml of hexane, shake the solution for 3 min mechanically, centrifuge for 2 min at 3000 rpm, and measure the absorbance of the extracts at 230 nm in 1 cm quartz cells. The percent extraction of methamphetamine by UV spectrophotometry was 100±3% and the lipid interference was suppressed. This method is simple, inexpensive and effective as the pre-treatment for the GC-MS determination.
社団法人日本分析化学会の論文
1986-01-05