ピルビン酸醗酵に關する研究(第5報) : ピルビン酸の蓄積を阻止する3つの型に就て

概要

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(1) The accumulation of pyruvic acid by Mucor mandshuricus SAITO is depressed by the following three causes.a) First, when the flowing path, from reactive pyruvic acid to ethanol, is made smooth by the action of a group of substances, namely, B_1,SB_1 (3(2'-methyl-4'-amino-pyrimidyl-5')-methyl-4-methyl-5-β-hydroxyethyl-thiothiazolone), B_1-pyrimidine, B_1-disulfide or benzothiazolo-B_1,the probability of stabilizing the pyruvic acid may be depressed.b) Second, substances of another group inhibit directly the "pyruvic acid stabilizing factor". Inhibitors such as p-chloro-mercuribenzoate, monoiodo-acetic acid and barium ion, and B_1-homologues such as oxy-B_1 and oxy-SB_1 are included in this group.c) And third, the mechanism of the action of vitamin B_2 is a little different from the first group. It activates the oxidizing system instead of anaerobic fermentation, but the resulting effect on the pyruvic acid accumulation is similar to the first group.(2) M. mandshuricus can be conviniently used for determining the anti-beriberi activities of certain B_1-homologues. For example, the activities of B_1-disulfide and SB_1,determined as 1 and 1/(1.3) respectively by this method, coincided with those which had been determined by employing the methods of white rat (ZIMA et al. for B_1-disulfide) or rice bird (NINOMIYA for SB_1).
社団法人日本生物工学会の論文
1952-07-15