Controlled Trial of the Effects of Milk Basic Protein (MBP) Supplementation on Bone Metabolism in Healthy Adult Women

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概要

• 論文の詳細を見る

• Milk has more beneficial effects on bone health compared to other food sources. Recent in vitro and in vivo studies showed that milk whey protein, especially its basic protein fraction, contains several components capable of both promoting bone formation and inhibiting bone resorption. However, the effects of milk basic protein (MBP) on bone metabolism of humans are not known. The object of this study was to examine the effects of MBP on bone metabolism of healthy adult women. Thirty-three normal healthy women were randomly assigned to treatment with either placebo or MBP (40 mg per day) for six months. The bone mineral density (BMD) of the left calcaneus of each subject was measured at the beginning of the study and after six months of treatment, by dual-energy x-ray absorptiometry. Serum and urine indices of bone metabolism were measured at the base line, three-month intervals, and the end of the study. Daily intake of nutrients was monitored by a three-day food record made at three and six months. The mean (±SD) rate of left calcaneus BMD gain of women in the MBP group (3.42±2.05%) was significantly higher than that of women in the placebo group (2.01±1.75%, P=0.042). As compared with the placebo group, urinary cross-linked N-teleopeptides of type-I collagen/creatinine and deoxypyridinoline/creatinine were significantly decreased in the MBP group (p<0.05), while no significant differences between the two groups were observed in serum osteocalcin and bone-specific alkaline phosphatase concentrations. A daily MBP supplementation of 40 mg in healthy adult women can significantly increase their BMD independent of dietary intake of minerals and vitamins. This increase in BMD might be primarily mediated through inhibition of osteoclast-mediated bone resorption by the MBP supplementation.

• 社団法人日本農芸化学会の論文
• 2001-04-23

著者

• Toba Y

  Snow Brand Milk Products Co. Ltd. Saitama Jpn

• Toba Yasuhiro

  Technology And Research Institute Snow Brand Milk Products Co. Ltd.

• Takada Yukihiro

  雪印乳業技術研究所

• YAMAMURA Jun-ichi

  Technology and Research Institute, Snow Brand Milk Products Co., Ltd.

• TAKADA Yukihiro

  Technology and Research Institute, Snow Brand Milk Products Co., Ltd.

• KAWAKAMI Hiroshi

  Technology and Research Institute, Snow Brand Milk Products Co., Ltd.

• KUMEGAWA Masayoshi

  Department of Oral Anatomy, Meikai University School of Dentistry

• AOE Seiichiro

  Technology and Research Institute, Snow Brand Milk Products Co., Ltd.

• ITABASHI Akira

  Central Clinical Laboratory, Saitama Medical School

• AOE Seicihiro

  Product Planning Department, Snow Brand Milk Products Co.Ltd.

• YAHIRO Masatoshi

  Product Planning Department, Snow Brand Milk Products Co.Ltd.

• Aoe Seicihiro

  Technology And Research Institute Snow Brand Milk Products Co. Ltd.

• Morita Y

  Japan Advanced Inst. Of Sci. And Technol. School Of Materials Sci. Ishikawa

• Morita Y

  Kyoto Univ. Kyoto‐shi

• Takada Y

  Snow Brand Milk Products Co. Ltd. Saitama Jpn

• Toba Y

  Technology And Research Institute Snow Brand Milk Products Co. Ltd.

• Takada Y

  Hokkaido Univ. Hokkaido Jpn

• Takada Yasuhiro

  Hokkaido Univ. Sapporo Jpn

• Aoe Seiichiro

  Technology And Research Institute Snow Brand Milk Products Co. Ltd.

• Takeuchi Yoji

  Cell Function And Structure Division Of Biological Sciences Graduate School Of Science Hokkaido Univ

• Yamamura Jun-ichi

  Department Of Virology Toyama Medical And Pharmaceutical University

• Yamamura Jun-ichi

  Technology And Research Institute Snow Brand Milk Products Co. Ltd.

• Morita Y

  Central Research Institute Tsukuba R&d Center Fuji Oil Co. Ltd.

• Yahiro Masatoshi

  Technology And Research Institute Snow Brand Milk Products Co. Ltd.

• Morita Yoshikazu

  Technology And Research Institute Snow Brand Milk Products Co. Ltd.

• Kumegawa Masayoshi

  Department Of Oral Anatomy Josai Dental University

• Aoe Seiichiro

  Product Planning Department Snow Brand Milk Products Co. Ltd.

• Takeda Yuichi

  Fac. Sci. And Tech. Keio Univ. Yokohama

• Itabashi Akira

  Central Clinical Laboratory Saitama Medical School

• Kawakami H

  Technology And Research Institute Snow Brand Milk Products Co. Ltd.

• Yahiro Masatoshi

  Product Planning Department Snow Brand Milk Products Co.ltd.

• Kawakami Hiroshi

  Technical Research Institute Snow Brand Milk Products Co. Ltd.

• TAKADA Yukihiro

  Technology and Research Institute, and Nutritional Science Laboratory

• TAKADA Yukihiro

  Technology & Research Institute, Snow Brand Milk Products Co., Ltd.

• TOBA Yasuhiro

  Technology & Research Institute, Snow Brand Milk Products Co., Ltd.

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